Reference
"A genome-wide association study confirms PNPLA3
and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
"
Stephan Buch, Felix Stickel, Eric Trépo, Michael Way, Alexander Herrmann, Hans Dieter Nischalke,
Mario Brosch, Jonas Rosendahl, Thomas Berg, Monika Ridinger, Marcella Rietschel, Andrew McQuillin,
Josef Frank, Falk Kiefer, Stefan Schreiber, Wolfgang Lieb, Michael Soyka, Nasser Semmo, Elmar Aigner,
Christian Datz, Renate Schmelz, Stefan Brückner, Sebastian Zeissig, Anna-Magdalena Stephan, Norbert Wodarz,
Jacques Devière, Nicolas Clumeck, Christoph Sarrazin, Frank Lammert, Thierry Gustot, Pierre Deltenre,
Henry Völzke, Markus M Lerch, Julia Mayerle, Florian Eyer, Clemens Schafmayer, Sven Cichon, Markus M Nöthen,
Michael Nothnagel, David Ellinghaus, Klaus Huse, Andre Franke, Steffen Zopf, Claus Hellerbrand,
Christophe Moreno, Denis Franchimont, Marsha Y Morgan, Jochen Hampe
Nature Genetics: Received 2 June; accepted 14 September; published online 19 October 2015; doi:10.1038/ng.3417
online
Additional Supplementary Material for the manuscript
Primary Discovery Meta-analysis (unadjusted) :
meta.alc_cirrhosis.GER.UK.primary_analyis.txt.gz
Genome-wide association meta-analysis of 712 cases with alcohol-related cirrhosis and 1,466 controls. P values are reported for SNPs that passed quality control. Only SNPs present in both cohorts are reported. Header abbreviations are detailed below.
Secondary Discovery Meta-analysis (adjusted) :
meta.alc_cirrhosis.GER.UK.secondary_adjusted_analysis.txt.gz
Genome-wide meta-analysis adjusted for age, sex, BMI and type 2 diabetes of 456 cases with alcohol-related cirrhosis and 873 controls in whom complete covariate information was available. P values are reported for SNPs that passed quality control. Only SNPs present in both cohorts are reported. Header abbreviations are detailed below.
Meta-analysis header details :
chr | Chromosome number |
rsid | SNP id |
pos | Base-pair position of SNP |
allele_A | non-coded allele |
allele_B | coded allele |
P_value | combined p-value. |
beta | combined effect size. |
se | combined standard error of effect size. |
Q | Cochran's Q statistics. |
P_heterogeneity | p-value for heterogeneity. |
I2 | percentage of total variation across studies that is due to heterogeneity. |
P_ Germany, P_UK | p-values of cohort 1, cohort 2. |