Reference

"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis "

Stephan Buch, Felix Stickel, Eric Trépo, Michael Way, Alexander Herrmann, Hans Dieter Nischalke, Mario Brosch, Jonas Rosendahl, Thomas Berg, Monika Ridinger, Marcella Rietschel, Andrew McQuillin, Josef Frank, Falk Kiefer, Stefan Schreiber, Wolfgang Lieb, Michael Soyka, Nasser Semmo, Elmar Aigner, Christian Datz, Renate Schmelz, Stefan Brückner, Sebastian Zeissig, Anna-Magdalena Stephan, Norbert Wodarz, Jacques Devière, Nicolas Clumeck, Christoph Sarrazin, Frank Lammert, Thierry Gustot, Pierre Deltenre, Henry Völzke, Markus M Lerch, Julia Mayerle, Florian Eyer, Clemens Schafmayer, Sven Cichon, Markus M Nöthen, Michael Nothnagel, David Ellinghaus, Klaus Huse, Andre Franke, Steffen Zopf, Claus Hellerbrand, Christophe Moreno, Denis Franchimont, Marsha Y Morgan, Jochen Hampe

Nature Genetics: Received 2 June; accepted 14 September; published online 19 October 2015; doi:10.1038/ng.3417 online



Additional Supplementary Material for the manuscript

Primary Discovery Meta-analysis (unadjusted) : meta.alc_cirrhosis.GER.UK.primary_analyis.txt.gz
Genome-wide association meta-analysis of 712 cases with alcohol-related cirrhosis and 1,466 controls. P values are reported for SNPs that passed quality control. Only SNPs present in both cohorts are reported. Header abbreviations are detailed below.

Secondary Discovery Meta-analysis (adjusted) : meta.alc_cirrhosis.GER.UK.secondary_adjusted_analysis.txt.gz
Genome-wide meta-analysis adjusted for age, sex, BMI and type 2 diabetes of 456 cases with alcohol-related cirrhosis and 873 controls in whom complete covariate information was available. P values are reported for SNPs that passed quality control. Only SNPs present in both cohorts are reported. Header abbreviations are detailed below.

Meta-analysis header details :

chrChromosome number
rsidSNP id
posBase-pair position of SNP
allele_Anon-coded allele
allele_Bcoded allele
P_valuecombined p-value.
betacombined effect size.
secombined standard error of effect size.
QCochran's Q statistics.
P_heterogeneityp-value for heterogeneity.
I2percentage of total variation across studies that is due to heterogeneity.
P_ Germany, P_UKp-values of cohort 1, cohort 2.